A REVIEW OF PALMITOYLETHANOLAMIDE

2015). These scientific studies, taken collectively, advise that, Even though a direct activation of GPR55 or PPAR‐α happens, PEA can deliver its anti‐inflammatory motion within the gut also by way of indirect activation of CB1 and CB2 receptors, likely as a consequence of the flexibility of the compound to potentiate the action of endocannabi

2016a). This scaled-down boost was proportionate to the smaller peak of PEA degrees detected in human volunteers as opposed with beagle canines. This big difference, subsequently, is often due to the reduced complete level of PEA acutely administered to human volunteers (about ∼5 vs. 30 mg·kg−1 in canines) and to the fact that this was a micr